Tetrahydrofuran → HCID 57505643、化合物

HRID 1663906

反応式

HRID 1663906 の反応式
[CH3:1][CH:2]1[CH2:4][CH:3]1[C:5]([OH:7])=O.O1CCCC1.C(Cl)(=O)C(Cl)=O.Cl.[NH2:20][C:21]1[N:22]=[C:23]2[CH:28]=[CH:27][C:26]([O:29][C:30]3[CH:31]=[CH:32][C:33]([CH3:46])=[C:34]([NH:36][C:37]([C:39]4[N:43]([CH3:44])[N:42]=[C:41]([CH3:45])[CH:40]=4)=[O:38])[CH:35]=3)=[N:25][N:24]2[CH:47]=1>CN(C)C=O.CN(C)C(=O)C>[CH3:44][N:43]1[C:39]([C:37]([NH:36][C:34]2[CH:35]=[C:30]([O:29][C:26]3[CH:27]=[CH:28][C:23]4[N:24]([CH:47]=[C:21]([NH:20][C:5]([CH:3]5[CH2:4][CH:2]5[CH3:1])=[O:7])[N:22]=4)[N:25]=3)[CH:31]=[CH:32][C:33]=2[CH3:46])=[O:38])=[CH:40][C:41]([CH3:45])=[N:42]1

参加物

7

反応物 4

HCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 998732-Methylcyclopropanecarboxylic acidHCID 57505635N-{5-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]-2-methylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide hydrochloride

生成物 1

HCID 57505643HCID 57505643、化合物収率 70.3%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 31374Dimethylacetamide溶媒

実験手順

In the same manner as in Example 279 and using 2-methylcyclopropanecarboxylic acid (97 mg, 0.97 mmol), tetrahydrofuran (1.5 mL), N,N-dimethylformamide (1 drop), oxalyl chloride (83 μL, 0.97 mmol), N-{5-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]-2-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide hydrochloride (200 mg, 0.48 mmol) and N,N-dimethylacetamide (5 mL) as starting materials, the title compound (155 mg, 70%) was obtained as a white solid.

出典と根拠

ORDレコード
ord-492fa512af824c45a6af121ca6f5ad3a
出典データセット
uspto-grants-2011_10
特許番号
US08034812B2

関連ノート

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