Ethyl Acetate → 5-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester

HRID 1664208

反応式

HRID 1664208 の反応式
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[C:6]([C:7]([NH:9][CH2:10][CH:11](OC)[O:12]C)=[O:8])[CH:5]=1.C(OCC)(=O)C>C1COCC1.Cl>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[C:6]([C:7]([NH:9][CH2:10][CH:11]=[O:12])=[O:8])[CH:5]=1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 67439609N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester

生成物 1

HCID 866265795-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 29.7 g (95.1 mmol) of N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester in 300 ml of THF and 300 ml of 2N HCl is stirred overnight. Ethyl acetate is added, and the mixture is washed twice with brine. The organic phase is dried over sodium sulfate and evaporated to yield the product in the form of a yellow oil.

後処理

  1. washthe mixture is washed twice with brine
  2. dry with materialThe organic phase is dried over sodium sulfate
  3. customevaporated
  4. customto yield the product in the form of a yellow oil

出典と根拠

ORDレコード
ord-1612f793da6a4beda7e6ce3a5b6b8e03
出典データセット
uspto-grants-2011_10
特許番号
US08039455B2

関連ノート

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