Methyl iodide → 6-Bromo-1-methyl-1H-indazole
反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][CH:3]=1.[OH-].[K+].[CH3:13]I>CO.C(OCC)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:13])=[CH:4][CH:3]=1参加物
6
実験手順
6-Bromoindazole (400 mg) was dissolved in methanol (10 mL). To this solution, potassium hydroxide (450 mg) was added followed by methyl iodide (0.50 mL) and the mixture was refluxed for 2.5 h. The reaction was cooled, diluted with diethyl ether, washed with water, brine, dried and concentrated. The product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash.
後処理
- temperaturethe mixture was refluxed for 2.5 h
- temperatureThe reaction was cooled
- washwashed with water, brine
- customdried
- concentrationconcentrated
- customThe product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash
出典と根拠
- ORDレコード
- ord-f391e8ec558c4f93a563fe826edb395a
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08039471B2
反応ノート
読み込み中…