Water → HCID 66736400、化合物
反応式
[CH3:1][O:2][C:3]1[CH:4]=[N:5][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:13]=[O:14])[C:11]=2[N:12]=1.[BH4-].[Na+].C1COCC1.O>CCO>[CH3:1][O:2][C:3]1[CH:4]=[N:5][C:6]2[C:11]([N:12]=1)=[C:10]([CH2:13][OH:14])[CH:9]=[CH:8][CH:7]=2参加物
6
反応条件
- 温度
- 0 °C
実験手順
To a stirred suspension of 3-methoxy-quinoxaline-5-carbaldehyde (prepared as described in WO 2006/032466, 5.0 g, 26.57 mmol) in EtOH (200 mL) cooled at 0° C., NaBH4 (1.1 g) was added in one portion. The reaction mixture was warmed to rt and THF (50 mL) was added. A clear solution was obtained. The mixture was further stirred at rt for 30 min. Water (200 mL) was added and the volatiles were removed in vacuo. The residue was filtered off, washed with water. The solid was dried under HV to afford the title alcohol as a brown solid (4.8 g, 95% yield).
後処理
- temperatureThe reaction mixture was warmed to rt
- customA clear solution was obtained
- customthe volatiles were removed in vacuo
- filtrationThe residue was filtered off
- washwashed with water
- customThe solid was dried under HV
出典と根拠
- ORDレコード
- ord-f5763d6eae1442a2940940928047c778
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08044044B2
反応ノート
読み込み中…