Thionyl Chloride → 4-Isopropoxy-3-methyl-benzoyl chloride

HRID 1666595ノート

反応式

HRID 1666595 の反応式
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][C:6]=1[CH3:14])([CH3:3])[CH3:2].S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:17])=[O:10])=[CH:7][C:6]=1[CH3:14])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 592729354-Isopropoxy-3-methylbenzoic acid

生成物 1

HCID 874026094-Isopropoxy-3-methyl-benzoyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of 4-isopropoxy-3-methyl-benzoic acid (1.35 g, 6.95 mmol) in chloroform (20 mL), thionylchloride (2.48 g, 20.9 mmol) is added. The mixture is refluxed for 2 h before the solvents are removed in vacuo to give crude 4-isopropoxy-3-methyl-benzoic acid chloride; LC-MS: tR=1.00 min.

後処理

  1. temperatureThe mixture is refluxed for 2 h before the solvents
  2. customare removed in vacuo

出典と根拠

ORDレコード
ord-3dd2f232704e4f738e15288e82bcbccd
出典データセット
uspto-grants-2011_10
特許番号
US08044076B2

反応ノート

読み込み中…