2-(Isopropylsulfonyl)-5-nitrobenzonitrile → 5-Amino-2-(isopropylsulfonyl)benzonitrile

HRID 1667610ノート

反応式

HRID 1667610 の反応式
[CH:1]([S:4]([C:7]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][C:8]=1[C:9]#[N:10])(=[O:6])=[O:5])([CH3:3])[CH3:2]>C1COCC1.[Pd]>[NH2:15][C:12]1[CH:13]=[CH:14][C:7]([S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])=[C:8]([CH:11]=1)[C:9]#[N:10]

参加物

4

反応物 1

HCID 574482062-(Isopropylsulfonyl)-5-nitrobenzonitrile

生成物 1

HCID 574482075-Amino-2-(isopropylsulfonyl)benzonitrile収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To 2-(isopropylsulfonyl)-5-nitrobenzonitrile (15B) (1.26 g, 4.96 mmol) in THF (20 mL) was added Pd/C (cat.) and the mixture was hydrogenated at 50 psi overnight. The reaction was filtered to provide 15C (1.09 g). LC-MS: 225.3 (M+H)+.

後処理

  1. customwas hydrogenated at 50 psi overnight
  2. filtrationThe reaction was filtered

出典と根拠

ORDレコード
ord-ca001710f8b740baba3b47db7d46c0c7
出典データセット
uspto-grants-2011_10
特許番号
US08044242B2

反応ノート

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