Ethylenediaminetetraacetic Acid → Octinoxate

HRID 1668275

反応式

CCCCCCCCC[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21]OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO.[CH3:80][CH2:81][CH2:82][CH2:83]CCCCCCCCCCCCCCOCCO.[C:102](OCC(CO)O)(=[O:116])CCCCCCCCCCCCC.[CH3:123][C:124]1C=C(C(C)(C)C)C(O)=C(C(C)(C)C)C=1.[O:139](C(O)C)C1C=CC=CC=1.C(OC(C1C=CC(O)=CC=1)=O)CCC.C(N(CC(O)=O)CC(O)=O)CN(CC(O)=O)CC(O)=O.[OH-].[K+].CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO>O.OCC(CO)O>[CH3:80][CH2:81][CH2:82][CH2:83][CH:21]([CH2:20][O:19][C:18](/[CH:17]=[CH:16]/[C:15]1[CH:14]=[CH:13][C:12]([O:116][CH3:102])=[CH:11][CH:10]=1)=[O:139])[CH2:123][CH3:124]

参加物

反応条件

温度: 80 °C

実験手順

The hyperbranched chromophore II (5.0 g, corresponding to 5% (w/w) UV-filter/sunscreen) was dissolved in Tegosoft TN at 80° C. and added to a mixture of Brij 72 (INCI: Steareth-2) (2.0 g), Brij 721 (INCI: Steareth-21) (2.0 g), Lanette O (cetearyl alcohol) (2.0 g), Estol GMM 3650 (glyceryl monomyristate) (2.0 g), BHT (butylhydroxytoluene) (0.05 g) and Phenonip (phenoxyethanol and methyl-, ethyl-, propyl-, butylparaben) (0.8 g). The mixture was shortly heated to 80° C. in order to melt solid emulsifiers. To the still warm mixture (70-80° C.) a preheated solution (˜80° C.) of glycerin (4.0 g) and EDTA BD (0.1 g) in water (62.95 g) and subsequently 10% aqueous KOH (0.1 g) as well as Sepigel 305 (polyacrylamide and C13-C14 isoparaffin and Laureth-7) (1.0 g) were added slowly under continuous stirring. The resulting emulsion was stirred until a temperature of about 40° C. was reached, homogenized with 24,000 rpm using a ULTRA-TURRAX®, and finally stirred for an additional hour. Determination of the photostability of the novel polymeric chromophore II was performed according to G. Berset et al. (International Journal of Cosmetic Science 1996, 18(3), 167-177) applying instead of a liquid film the prepared sunscreen. Thereby 96% of the chromophore II could have been recovered. In vitro SPF measurements were performed in comparison to a sunscreen containing 5% Parsol® MCX (2-ethylhexyl 4-methoxycinnamate) after application of 1.4 mg sunscreen per cm2 on PMMA plates (Helioscience, Marseille, FR) using the SPF-290S Analyzer System (Optometrics LLC, Chicago, US). Each in vitro SPF was determined in triplicate to give for chromophore II and Parsol® MCX an average of 6.6 (II) and 6.8, respectively.

後処理

stirringhomogenized with 24,000 rpm
stirringfinally stirred for an additional hour
customThereby 96% of the chromophore II could have been recovered
additioncontaining 5% Parsol® MCX (2-ethylhexyl 4-methoxycinnamate) after application of 1.4 mg

出典と根拠

ORDレコード: ord-78bf407f491a4067be0fdf0f4cc3ebff
出典データセット: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07988953B2

反応式

参加物

反応物 9

生成物 1

試薬・触媒・溶媒 2

反応条件

実験手順

後処理

出典と根拠

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