Hydrochloric Acid → 3-[4-(3-Methyl-4'-trifluoromethyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid

HRID 1669263ノート

反応式

HRID 1669263 の反応式
C[O:2][C:3](=[O:34])[CH2:4][CH2:5][NH:6][C:7](=[O:33])[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)=[CH:18][C:17]=2[CH3:32])=[CH:10][CH:9]=1.[OH-].[Na+].Cl>C1COCC1>[CH3:32][C:17]1[CH:18]=[C:19]([C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:29])([F:31])[F:30])=[CH:26][CH:27]=2)[CH:20]=[CH:21][C:16]=1[CH2:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:34])=[O:2])=[O:33])=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 673435023-[4-(3-Methyl-4'-trifluoromethyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid methyl ester

生成物 1

HCID 115833753-[4-(3-Methyl-4'-trifluoromethyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

A mixture of 3-[4-(3-methyl-4′-trifluoromethyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid methyl ester (0.11 g) and 5M NaOH (1.5 mL) in THF (3 mL) is heated to 70° C. for 12 h. The mixture is acidified with 5M HCl, and extracted with EtOAc. The organics are washed with water and brine, and dried with MgSO4 to yield the title compound. MS (ES): 458 (M+). The structure is also confirmed by 1H NMR.

後処理

  1. extractionextracted with EtOAc
  2. washThe organics are washed with water and brine
  3. dry with materialdried with MgSO4

出典と根拠

ORDレコード
ord-606a4a837e8641bb8413e0c83a56d6e4
出典データセット
uspto-grants-2011_08
特許番号
US07989457B2

反応ノート

読み込み中…