Nitric Acid → HCID 57433540、化合物

HRID 1671663ノート

反応式

HRID 1671663 の反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]>C(=O)([O-])[O-].[Na+].[Na+]>[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 57433539Methyl 2-fluoro-4-[(pyridine-2-carbonyl)amino]benzoate

生成物 1

HCID 57433540HCID 57433540、化合物

試薬・触媒・溶媒 1

HCID 10340Sodium Carbonate溶媒

実験手順

With cooling with ice, fuming nitric acid (110 ml) was gradually added to methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate (27.7 g), and stirred at room temperature for 1.5 hours. With cooling with ice, the reaction liquid was gradually added to an aqueous solution (2000 ml) of sodium carbonate (138 g), and the formed solid was taken out through filtration. After dried under reduced pressure, the entitled compound was obtained as a yellow solid.

後処理

  1. temperatureWith cooling with ice
  2. customthe reaction liquid
  3. filtrationthe formed solid was taken out through filtration
  4. customAfter dried under reduced pressure
  5. customthe entitled compound was obtained as a yellow solid

出典と根拠

ORDレコード
ord-f19ca06b113e4f64808c7f7153e5b9a6
出典データセット
uspto-grants-2011_08
特許番号
US07994331B2

反応ノート

読み込み中…