(2-Aminobenzo[d]thiazol-6-yl)methanol → 2-Aminobenzo[d]thiazole-6-carbaldehyde

HRID 1671779ノート

反応式

HRID 1671779 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH2:11][OH:12])[CH:8]=[CH:7][C:5]=2[N:6]=1>C1COCC1.O=[Mn]=O>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1

参加物

4

反応物 1

HCID 13821540(2-Aminobenzo[d]thiazol-6-yl)methanol

生成物 1

HCID 138215412-Aminobenzo[d]thiazole-6-carbaldehyde収率 87.6%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (2-aminobenzo[d]thiazol-6-yl)methanol (1.90 g, 10.5 mmol, 1.0 eq.) in THF (75 mL) under nitrogen was added MnO2 (14 g, 161 mmol, 15.3 eq.). After stirring overnight, the reaction solution was filtered through Celite and rinsed with THF. The filtrate was concentrated in vacuo to give 2-aminobenzo[d]thiazole-6-carbaldehyde as a yellow solid (1.64 g, 87% yield).

後処理

  1. filtrationthe reaction solution was filtered through Celite
  2. washrinsed with THF
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-05f5610282424195ac3c433ced116840
出典データセット
uspto-grants-2011_08
特許番号
US07994337B2

反応ノート

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