Vinyl Acetate → HCID 178525781、化合物

HRID 1674286

反応式

HRID 1674286 の反応式
[C:1]([O:9][CH:10]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC=C)(=O)C>C(OC(C)C)(C)C>[C:1]([O:9][C@H:10]1[CH2:15][CH2:14][C@@H:13]([OH:16])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 7904Vinyl AcetateHCID 2381094-Hydroxycyclohexyl benzoate

生成物 1

HCID 178525781HCID 178525781、化合物収率 46%

試薬・触媒・溶媒 1

HCID 7914Diisopropyl Ether溶媒

実験手順

To a solution of 4-hydroxycyclohexyl benzoate (81.5 g) and Lipase QLG (40 g) in diisopropyl ether (800 mL) was added vinyl acetate (120 mL) at room temperature. After being stirred at room temperature for 2 hr, Lipase QLG was filtered off. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound as a colorless solid (37.5 g, 46%).

後処理

  1. filtrationLipase QLG was filtered off
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-9452e169fac44bedba91133d72773432
出典データセット
uspto-grants-2011_08
特許番号
US07998968B2

関連ノート

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