O=C1CCC(=O)N1O[C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][CH:11]=1.BrC1C=CC(C(O)=O)=CC=1.ONC(=O)CCC(N)=O.[NH:37]1[CH2:41][CH2:40][CH2:39][C@H:38]1[CH2:42][N:43]1[CH2:47][CH2:46][CH2:45][CH2:44]1>O1CCCC1>[Br:16][C:13]1[CH:12]=[CH:11][C:10]([C:9]([N:37]2[CH2:41][CH2:40][CH2:39][C@H:38]2[CH2:42][N:43]2[CH2:47][CH2:46][CH2:45][CH2:44]2)=[O:17])=[CH:15][CH:14]=1
Procedure X′: To a stirring solution of 4-bromobenzoic acid-2,5-dioxo-pyrrolidin-1-yl ester (3.5 g, 11.7 mmol), [which can be prepared from 4-bromobenzoic acid and N-hydroxy succinamide by the method of C. Mitsos, Chem Pharm Bull 48(2), 211-214 (2000), or purchased from Ambinter, CAS#80586-82-9], in tetrahydrofuran (0.15M), add (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine and heat to reflux for four hours. After this time, remove the heat and wash the reaction with water while extracting with 10% isopropanol/dichloromethane. Dry the organics with sodium sulfate, filter and concentrate in vacuo. Purify on a silica column eluting with 2M ammonia in methanol and dichloromethane to give (4-bromo-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-yl)methanone (93% yield with 80% purity). MS (m/e): 337.1 (M+1)
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