1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

温度

0 °C

To a cold (0° C.) solution of 1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinecarboxylic acid (3.68 g, 16.1 mmol, 1.00 equiv), {[2-(trifluoromethyl)phenyl]methyl}amine (2.57 mL, 18.3 mmol, 1.14 equiv), and DMAP (392 mg, 3.21 mmol, 0.200 equiv) in CH2Cl2 (100 mL) was added diisopropylethylamine (DIEA, 3.49 ml, 20.1 mmol, 1.25 equiv) and EDCI (3.11 g, 20.1 mmol, 1.25 equiv). The reaction mixture was stirred at 0° C. for 30 min and then at room temperature overnight. The solution was washed with H2O, sat NaHCO3 (aq) and brine. The organic layer was dried over Na2SO4, filtered, and concentrated. The residue was stirred in CH2Cl2 (60 mL) and TFA (60 mL) for 20 min at room temperature, and then the solvents were removed in vacuo. The residue was diluted with CH2Cl2, and the resulting solution was neutralized carefully with sat NaHCO3 (aq). Solid NaCl was used to saturate the aqueous layer, which was then extracted 3 times with ethyl acetate. The organic layers were combined, dried with Na2SO4, filtered and concentrated to afford 4.43 g (97% yield) of the desired product. MS (ES+): m/e 287.0 [M+H]+.

1. customat room temperature
2. customovernight
3. washThe solution was washed with H2O
4. dry with materialThe organic layer was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. stirringThe residue was stirred in CH2Cl2 (60 mL)
8. waitTFA (60 mL) for 20 min at room temperature
9. customthe solvents were removed in vacuo
10. additionThe residue was diluted with CH2Cl2
11. concentrationto saturate the aqueous layer, which
12. extractionwas then extracted 3 times with ethyl acetate
13. dry with materialdried with Na2SO4
14. filtrationfiltered
15. concentrationconcentrated

ORDレコード

ord-5c8edec3ee6549f89c392801857898b8

出典データセット

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08008483B2