Hydrochloric Acid → (5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

HRID 1679676ノート

反応式

HRID 1679676 の反応式
[C:1]([C:3]1[O:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[C:4]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)#[N:2].B#B.Cl>O1CCCC1>[ClH:12].[NH2:2][CH2:1][C:3]1[O:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[C:4]=1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6328200DiboronHCID 227634675-Chloro-3-phenyl-1-benzofuran-2-carbonitrile

生成物 1

HCID 22763506(5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Treat 2.0 g. of 2-cyano-5-chloro-3-phenylbenzo[b]furan (0.008 mole) in 30 ml. of tetrahydrofuran with 18 ml. of diborane in tetrahydrofuran (1 M solution) and reflux for 2 hours. Cool, add 10 ml. of 10% hydrochloric acid and reflux for 1/2 hour. Evaporate the solution to dryness and dissolve the residue in 50 ml. of ethanol. Add 30 ml. of ethanol saturated with hydrogen chloride. Dry the precipitate obtained to yield the title compound; m.p. 254°-256°.

後処理

  1. additionTreat 2.0 g
  2. temperatureCool
  3. additionadd 10 ml
  4. customEvaporate the solution to dryness
  5. dissolutiondissolve the residue in 50 ml
  6. additionAdd 30 ml
  7. customDry the precipitate
  8. customobtained

出典と根拠

ORDレコード
ord-cf457f7b0ccc4728ac007292c0efcc4d
出典データセット
uspto-grants-1978_03
特許番号
US04081549

反応ノート

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