Hydrochloric Acid → 3,5-Diamino-8-chloro-2,3-dihydro-quinoline-4-one

HRID 1683492ノート

反応式

HRID 1683492 の反応式
Cl.C([N:5]1[C:14]2[C:9](=[C:10]([NH:16]C(=O)C)[CH:11]=[CH:12][C:13]=2[Cl:15])[C:8](=[O:20])[CH:7]([NH:21]C(=O)C)[CH2:6]1)(=O)C.[OH-].[Na+]>C(Cl)(Cl)Cl>[NH2:21][CH:7]1[C:8](=[O:20])[C:9]2[C:14](=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[NH2:16])[NH:5][CH2:6]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 224495101-Acetyl-3,5-diacetylamino-8-chloro-2,3-dihydro-quinoline-4-one

生成物 1

HCID 224495153,5-Diamino-8-chloro-2,3-dihydro-quinoline-4-one

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
110 °C

実験手順

8 ml of 6N hydrochloric acid was added to 514 mg of the compound prepared in (2) above, and the mixture was heated at 110° C. for 1.5 hours while stirring. After cooling chloroform was added to it, followed by the addition of 50 ml of 1N aqueous solution of sodium hydroxide while stirring. The chloroform layer was extracted, the extract was washed with saturated brine and dried over anhydrous sodium sulfate. The product was concentrated to produce 260 mg of the title compound.

後処理

  1. additionwas added to it
  2. stirringwhile stirring
  3. extractionThe chloroform layer was extracted
  4. washthe extract was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationThe product was concentrated

出典と根拠

ORDレコード
ord-fe4b9b068e13462192558088df62be4e
出典データセット
uspto-grants-1997_06
特許番号
US05637770

反応ノート

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