Isopropylamine → HCID 86661277、化合物

HRID 1685008ノート

反応式

HRID 1685008 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]I)[N:14]=1)=[O:8].[CH:21]([NH2:24])([CH3:23])[CH3:22]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][NH:24][CH:21]([CH3:23])[CH3:22])[N:14]=1)=[O:8]

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 58055059HCID 58055059、化合物

生成物 1

HCID 86661277HCID 86661277、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The 1-(3,4-Dichloro-benzyl)-3-(4-iodomethyl-thiazol-2-yl)-urea intermediate (0.3 mmol) was taken up in tetrahydrofuran (5 ml) and isopropyl amine (20 eq.) was added. The reaction was stirred overnight at room temperature. Added a saturated solution of NaSO3 (40 ml). Extracted this with EtOAc twice. The combined organic extracts were dried over Na2SO4, filtered and solvent removed in vacuo. The crude 1-(3,4-dichlorobenzyl)-3-(4-((isopropylamino)methyl)thiazol-2-yl)urea was used as is.

後処理

  1. extractionExtracted this with EtOAc twice
  2. dry with materialThe combined organic extracts were dried over Na2SO4
  3. filtrationfiltered
  4. customsolvent removed in vacuo

出典と根拠

ORDレコード
ord-bec7f25a0b004b0f8d13a8dbeceae07b
出典データセット
uspto-grants-2012_04
特許番号
US08148380B2

反応ノート

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