Hydrogen Bromide → 2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid

HRID 1686424ノート

反応式

HRID 1686424 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([CH:13]([CH3:18])[C:14]([O:16]C)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.Br>C(O)(=O)C.[OH-].[Na+]>[OH:2][C:3]1[CH:4]=[C:5]([CH:13]([CH3:18])[C:14]([OH:16])=[O:15])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

参加物

5

反応物 2

HCID 260Hydrogen BromideHCID 66734169Methyl 2-[3-methoxy-5-(trifluoromethyl)phenyl]propanoate

生成物 1

HCID 667340972-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid収率 70%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 14798Sodium Hydroxide溶媒

反応条件

温度
100 °C

実験手順

The product from step (ii) (0.8 g) was dissolved in glacial acetic acid (20 ml) and treated with 48% aqueous HBr (20 ml). The mixture was heated at 100° C. for 16 h. The mixture was cooled and diluted with 2M NaOH, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to give an oil, which was purified by RPHPLC to give a colourless oil (0.5 g).

後処理

  1. temperatureThe mixture was cooled
  2. extractionextracted with ethyl acetate
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure
  5. customto give an oil, which
  6. customwas purified by RPHPLC

出典と根拠

ORDレコード
ord-9b82a0e8a97c492b9a6bc35743ac3cbc
出典データセット
uspto-grants-2012_04
特許番号
US08148572B2

反応ノート

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