Ethyl Bromide → 8-Ethyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine
反応式
[CH:1]1[C:6]2[CH2:7][NH:8][CH2:9][CH2:10][S:11][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:12].[CH2:13](N(C(C)C)C(C)C)[CH3:14].BrCC>C(Cl)Cl>[CH2:13]([N:8]1[CH2:7][C:6]2[CH:1]=[C:2]([NH2:12])[CH:3]=[CH:4][C:5]=2[S:11][CH2:10][CH2:9]1)[CH3:14]参加物
5
実験手順
To a solution of 6,7,8,9-tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine (0.07 g, 0.00039 mol) and N-ethyldiisopropylamine (0.066 g, 0.00047 mol) in DCM (4 mL) was added bromoethane (0.051 g, 0.00047 mol), stirred 20 h and evaporated to give 8-ethyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocyclohepten-2-ylamine (0.07 g) as an oil. MS (ESI+): 209 (M+H).
後処理
- customevaporated
出典と根拠
- ORDレコード
- ord-cdd656f2d8bf49228174508458aeee87
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08148391B2
反応ノート
読み込み中…