Acetic Acid → 4-Chloro-thiobenzoic acid hydrazide
反応式
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6](SCC(O)=O)=[S:7])=[CH:4][CH:3]=1.O.[NH2:16][NH2:17].C(O)(=O)C>[OH-].[Na+].C(Cl)Cl>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([NH:16][NH2:17])=[S:7])=[CH:4][CH:3]=1参加物
6
実験手順
To a mixture of (4-chloro-thiobenzoylsulfanyl)-acetic acid (8.31 mmol) in 9 mL of NaOH (1N) is added hydrazine hydrate (36.7 mL). Glacial acetic acid (2.7 mL) is then added to the solution and the mixture is vigorously stirred. The reaction mixture is diluted with CH2Cl2 and the organic layer dried over MgSO4 to yield 4-chloro-thiobenzoic acid hydrazide: LC/MS (ES+) 186.9 (M+1)+.
後処理
- dry with materialthe organic layer dried over MgSO4
出典と根拠
- ORDレコード
- ord-b99cc83e1a414d7ba05bd1fbf75332dc
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158662B2
反応ノート
読み込み中…