Dimethylformamide → 3-Chloro-4-iodo-N,N-dimethylbenzenesulfonamide

HRID 1694743ノート

反応式

HRID 1694743 の反応式
[H-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([S:11](N)(=[O:13])=[O:12])[CH:7]=[CH:8][C:9]=1[I:10].CI.[CH3:17][N:18]([CH:20]=O)C>>[Cl:3][C:4]1[CH:5]=[C:6]([S:11]([N:18]([CH3:20])[CH3:17])(=[O:12])=[O:13])[CH:7]=[CH:8][C:9]=1[I:10]

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 672810493-Chloro-4-iodobenzenesulfonamide

生成物 1

HCID 672802043-Chloro-4-iodo-N,N-dimethylbenzenesulfonamide

実験手順

Sodium hydride (0.33 g) was added to a solution of the product from step (i) (1.2 g) in DMF (25 ml) and stirred for 20 min. Methyl iodide (0.5 ml) was added dropwise and then stirred for a further 1 h. The reaction mixture was quenched with water, extracted with EtOAc, dried (MgSO4) and evaporated. The residue was treated with ether to give to give the subtitle compound as a white solid. Yield 0.45 g.

後処理

  1. stirringstirred for a further 1 h
  2. customThe reaction mixture was quenched with water
  3. extractionextracted with EtOAc
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. additionThe residue was treated with ether
  7. customto give

出典と根拠

ORDレコード
ord-8e940acfa8d143c38dcbfcb1a59be9ad
出典データセット
uspto-grants-2012_04
特許番号
US08158820B2

反応ノート

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