Propionitrile → 2-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile

HRID 1695182

反応式

HRID 1695182 の反応式
[NH2:1][C:2]1[CH:6]=[CH:5]NN=1.CO[C:9](=[O:20])[C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=1.[H-].[Na+].C(#N)CC>>[CH3:5][CH:6]([C:9](=[O:20])[C:10]1[CH:11]=[CH:12][C:13]([C:16]([F:17])([F:18])[F:19])=[CH:14][CH:15]=1)[C:2]#[N:1]

参加物

5

反応物 4

HCID 7854PropionitrileHCID 24758Sodium hydrideHCID 520447Methyl 4-(trifluoromethyl)benzoateHCID 178418806HCID 178418806、化合物

生成物 1

HCID 431572662-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile収率 96%

実験手順

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 4-trifluoromethyl-benzoic acid methyl ester (3.0 g, 14.7 mmol, 1.0 eq), NaH (1.2 g, 29.4 mmol, 2.0 eq) and propionitrile (4.9 mL, 69.4 mmol, 4.7 eq). The crude product was extracted with DCM and used in the following step without further purification (3.2 g, yield: 96%).

後処理

  1. customThe product was prepared
  2. extractionThe crude product was extracted with DCM
  3. customused in the following step without further purification (3.2 g, yield: 96%)

出典と根拠

ORDレコード
ord-bd720de13d4141079f412edd57df2be6
出典データセット
uspto-grants-2012_04
特許番号
US08163729B2

関連ノート

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