Acetonitrile → 3-(6-Methoxy-naphthalen-2-yl)-3-oxo-propionitrile

HRID 1695219ノート

反応式

HRID 1695219 の反応式
CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH3:16])[CH:11]=2)[CH:6]=1)=[O:4].[H-].[Na+].[C:19](#[N:21])[CH3:20]>C1(C)C=CC=CC=1>[CH3:16][O:15][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[CH:6]=[C:5]([C:3](=[O:4])[CH2:20][C:19]#[N:21])[CH:14]=[CH:13]2

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 24758Sodium hydrideHCID 604020Methyl 6-methoxy-2-naphthoate

生成物 1

HCID 671886013-(6-Methoxy-naphthalen-2-yl)-3-oxo-propionitrile

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
90 °C

実験手順

To a solution of 6-methoxy-naphthalene-2-carboxylic acid methyl ester (1.0 g, 4.7 mmol) in dry toluene (8 mL), NaH (0.55 mg, 9.4 mmol) were added and the mixture was heated at 90° C. To the hot solution, acetonitrile (1.2 mL) was added dropwise. The reaction was then heated for 18 hours and the product precipitated from the reaction mixture as its sodium salt.

後処理

  1. temperatureThe reaction was then heated for 18 hours
  2. customthe product precipitated from the reaction mixture as its sodium salt

出典と根拠

ORDレコード
ord-fd27605a8f18448884a75736b5b66078
出典データセット
uspto-grants-2012_04
特許番号
US08163729B2

反応ノート

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