Water → 4-Chloro-1H-pyrrolo[2,3-B]pyridine-3-carbonitrile

HRID 1696195ノート

反応式

HRID 1696195 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8](S(C3C=CC=CC=3)(=O)=O)[CH:9]=[C:10]([C:11]#[N:12])[C:3]=12.[OH-].[Na+].O>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[C:10]([C:11]#[N:12])[C:3]=12

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 497590871H-Pyrrolo[2,3-B]pyridine-3-carbonitrile, 4-chloro-1-(phenylsulfonyl)-

生成物 1

HCID 457903004-Chloro-1H-pyrrolo[2,3-B]pyridine-3-carbonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile was treated with 2M NaOH solution (4 ml) in tetrahydrofuran (8 ml) at ambient temperature for 1 hour. The reaction mixture was cooled and was added water. The aqueous layer was extracted with EtOAc. And the organic layer was washed with brine, dried over MgSO4 and concentrated. Resultings were purified by silica gel column chromatography to give 4-chloro-1H-pyrrolo[2,3-b]-pyridine-3-carbonitrile as colorless powder.

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionThe aqueous layer was extracted with EtOAc
  3. washAnd the organic layer was washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customResultings were purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-0cdd8dbf809e4beeb71196efdec39bcd
出典データセット
uspto-grants-2012_04
特許番号
US08163767B2

反応ノート

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