Water → 4-[3-t-Butyl-5-(3-naphthalen-1-yl-ureido)-pyrazol-1-yl]-benzoic acid ethyl ester

HRID 16978

反応式

HRID 16978 の反応式
[C:1]([C:5]1[CH:9]=[C:8]([NH2:10])[N:7]([C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:21]1([N:31]=[C:32]=[O:33])[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][CH:22]=1.O.[CH2:35]1COCC1>>[CH2:18]([O:17][C:15](=[O:16])[C:14]1[CH:13]=[CH:12][C:11]([N:7]2[C:8]([NH:10][C:32]([NH:31][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]=[CH:23][CH:22]=3)=[O:33])=[CH:9][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[N:6]2)=[CH:20][CH:19]=1)[CH3:35]

参加物

5

反応物 4

HCID 962WaterHCID 8028Tetrahydrofuran2 回HCID 66589alpha-Naphthyl isocyanateHCID 2973426methyl 4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoate

生成物 1

HCID 588428904-[3-t-Butyl-5-(3-naphthalen-1-yl-ureido)-pyrazol-1-yl]-benzoic acid ethyl ester

実験手順

To a solution of Example X (2.9 g, 10 mmol) in THF (50 mL) was added a solution of 1-naphthyl isocyanate (1.7 g, 10 mmol) in THF (20 mL) at 0° C. The mixture was stirred at RT for 1 h and heated until all solids dissolved. The mixture was then stirred at RT for 3 h and poured into water (200 mL). The precipitate was filtered, washed with diluted HCl and H2O, dried under vacuum to give 4.3 g of 4-[3-t-butyl-5-(3-naphthalen-1-yl-ureido)-pyrazol-1-yl]-benzoic acid ethyl ester, which was used without further purification.

後処理

  1. temperatureheated until all solids
  2. dissolutiondissolved
  3. stirringThe mixture was then stirred at RT for 3 h
  4. filtrationThe precipitate was filtered
  5. washwashed with diluted HCl and H2O
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-53edbb55c33848469d34fdbcb4972bf7
出典データセット
uspto-grants-2010_06
特許番号
US07737283B2

関連ノート

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