Ethyl isonicotinate → HCID 22388182、化合物

HRID 1699796ノート

反応式

HRID 1699796 の反応式
[C:1]([O:9][CH2:10][CH3:11])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[N+:12]([C:15]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:16]=1[O:24]N)([O-:14])=[O:13]>O1CCCC1>[N+:12]([C:15]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:16]=1[OH:24])([O-:14])=[O:13].[NH2:12][N:5]1[CH:6]=[CH:7][C:2]([C:1]([O:9][CH2:10][CH3:11])=[O:8])=[CH:3][CH2:4]1

参加物

4

反応物 2

HCID 15291Ethyl isonicotinateHCID 87140O-(2,4-dinitrophenyl)hydroxylamine

生成物 1

HCID 22388182HCID 22388182、化合物収率 99.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Ethyl isonicotinate (10.0 g) was dissolved in tetrahydrofuran (100 ml), and O-(2,4-dinitrophenyl)hydroxylamine (11.9 g) was added at room temperature, which was followed by refluxing under heating for 2 hr. The solvent was evaporated under reduced pressure, and the obtained residue was washed with diethyl ether and ethyl acetate to give the objective compound (10.5 g) as an amber-colored powder.

後処理

  1. temperatureby refluxing
  2. temperatureunder heating for 2 hr
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained residue was washed with diethyl ether and ethyl acetate

出典と根拠

ORDレコード
ord-b41c5c7d19764081a365283b1e3ac4e0
出典データセット
uspto-grants-2002_02
特許番号
US06348474B1

反応ノート

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