Chloroform → 1-Chloro-2-isocyano-3-methylbenzene

HRID 1702127ノート

反応式

HRID 1702127 の反応式
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[NH2:4].[CH:10](Cl)(Cl)Cl.[OH-].[Na+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl>[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[N+:4]#[C-:10]

参加物

6

反応物 3

HCID 6212ChloroformHCID 68972-Chloro-6-methylanilineHCID 14798Sodium Hydroxide

生成物 1

HCID 162174661-Chloro-2-isocyano-3-methylbenzene

試薬・触媒・溶媒 2

HCID 66133Benzyl triethylammonium chloride触媒HCID 6344Dichloromethane溶媒

実験手順

The procedure of Example 1 was again followed, using 100 g (0.7 mole) of 2-methyl-6-chloroaniline, 75 ml of chloroform, 100 ml of methylene chloride, 175 ml of 50% aqueous sodium hydroxide, and 1 g of benzyltriethylammonium chloride. The product was a solid weighing 44 g, with structure confirmed by mass spectroscopy.

出典と根拠

ORDレコード
ord-8d48991346e645769c5802957fe443aa
出典データセット
uspto-grants-1983_04
特許番号
US04380468

反応ノート

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