Piperidine → 6-Pentyl-6-methyl-2-oxo-1,4-oxathiane-3-acetic acid

HRID 1703810ノート

反応式

HRID 1703810 の反応式
C[O:2][C:3](=[O:19])[CH2:4][CH:5]([C:16]([OH:18])=[O:17])[S:6][CH2:7][C:8](O)([CH3:14])[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].O=S(Cl)Cl.N1CCCCC1>C(Cl)(Cl)Cl>[CH2:9]([C:8]1([CH3:14])[O:17][C:16](=[O:18])[CH:5]([CH2:4][C:3]([OH:2])=[O:19])[S:6][CH2:7]1)[CH2:10][CH2:11][CH2:12][CH3:13]

参加物

5

反応物 3

HCID 8082PiperidineHCID 24386Thionyl ChlorideHCID 544848136-Hydroxy-3-hydroxycarbonyl-6-methyl-4-thiaundecanoic acid methyl ester

生成物 1

HCID 227607726-Pentyl-6-methyl-2-oxo-1,4-oxathiane-3-acetic acid

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

2.7 g of 6-hydroxy-3-hydroxycarbonyl-6-methyl-4-thiaundecanoic acid methyl ester and 1.25 g of SOCl2 are stirred for 2 hours in 40 ml of chloroform at room temperature. The mixture is boiled briefly. After cooling, 0.5 ml of piperidine, dissolved in 20 ml of chloroform is added thereto. The resultant mixture is further stirred for 1 hour at 30°. After the usual working up, 6-pentyl-6-methyl-2-oxo-1,4-oxathiane-3-acetic acid is obtained.

後処理

  1. temperatureAfter cooling
  2. additionis added

出典と根拠

ORDレコード
ord-1ebe0ee7dd4b4508baebe09bfa0e7f6c
出典データセット
uspto-grants-1978_11
特許番号
US04125622

反応ノート

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