3-(4-Fluorophenoxy)propionic acid → 1-Propanol, 2-(4-fluorophenoxy)-

HRID 1704139ノート

反応式

HRID 1704139 の反応式
B#B.[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=1>O1CCCC1>[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[CH2:10][OH:11])=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 38721403-(4-Fluorophenoxy)propionic acidHCID 6328200Diboron

生成物 1

HCID 104647301-Propanol, 2-(4-fluorophenoxy)-収率 92.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To 95 ml of 1 Molar diborane in tetrahydrofuran is added 10.2 g of 2-(p-fluorophenoxy)propionic acid in 100 ml of tetrahydrofuran. The mixture is stirred at room temperature for 20 hrs. and poured onto 600 g of ice. The mixture is extracted with chloroform and the chloroform extracts dried (MgSO4). The solvent is removed under vacuum and the residual liquid distilled to give 8.7 g of colorless liquid.

後処理

  1. extractionThe mixture is extracted with chloroform
  2. dry with materialthe chloroform extracts dried (MgSO4)
  3. customThe solvent is removed under vacuum
  4. distillationthe residual liquid distilled

出典と根拠

ORDレコード
ord-10c47979acf6498c85bb2e4b89255ffb
出典データセット
uspto-grants-1978_11
特許番号
US04125732

反応ノート

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