Hydrogen Bromide → HCID 54386710、化合物

HRID 1704141ノート

反応式

HRID 1704141 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.CS(O[CH2:18][CH:19]([O:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)[CH3:20])(=O)=O.[Br:29]N1C(=O)CCC1=O.Br>CN(C)C(=O)C.C(Cl)(Cl)(Cl)Cl>[Br:29][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([O:1][CH2:18][CH:19]([O:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH3:20])=[CH:7][CH:6]=1)[C:9]([O:11][CH3:12])=[O:10]

参加物

7

反応物 4

HCID 260Hydrogen BromideHCID 67184N-bromobutanimideHCID 518900Benzeneacetic acid, 4-hydroxy-, methyl esterHCID 20378389HCID 20378389、化合物

生成物 1

HCID 54386710HCID 54386710、化合物

試薬・触媒・溶媒 2

HCID 5943Carbon Tetrachloride溶媒HCID 31374Dimethylacetamide溶媒

実験手順

As described in Example 68, 46 g of methyl p-hydroxyphenylacetate is reacted with 2-(p-Fluorophenoxy)-1-propanol O-methane-sulfonate in 400 ml of N,N-dimethylacetamide at 100° C. for 18 hrs. The product is dissolved in 1250 ml of carbon tetrachloride and N-bromosuccinimide added. Anhydrous HBr is added and the mixture is stirred and refluxed for 24 hrs. The mixture is filtered through a short column of silica gel and the solvent removed to give the product as a viscous oil.

後処理

  1. temperaturerefluxed for 24 hrs
  2. filtrationThe mixture is filtered through a short column of silica gel
  3. customthe solvent removed

出典と根拠

ORDレコード
ord-4f210e7120ed47c9addc43265f87b0d2
出典データセット
uspto-grants-1978_11
特許番号
US04125732

反応ノート

読み込み中…