Potassium Hydroxide → 5-Ethoxy-2-methyl-4-(2-methylpropyl)thiazole

HRID 1704181ノート

反応式

HRID 1704181 の反応式
[CH2:1]([O:3][C:4](=O)[C@H:5]([CH2:10][CH:11]([CH3:13])[CH3:12])[NH:6][C:7](=O)[CH3:8])[CH3:2].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:16].[OH-].[K+]>C(Cl)(Cl)Cl>[CH3:8][C:7]1[S:16][C:4]([O:3][CH2:1][CH3:2])=[C:5]([CH2:10][CH:11]([CH3:13])[CH3:12])[N:6]=1

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 14817Phosphorus sulfide (P2S5)HCID 1549286HCID 1549286、化合物

生成物 1

HCID 227589445-Ethoxy-2-methyl-4-(2-methylpropyl)thiazole

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A one liter three-neck flask equipped with a stirrer, condenser, and heating mantle is charged with 31.4 g (0.156 mole) of N-acetylleucine ethyl ester, 34.7 g (0.156 mole) of phosphorus pentasulfide, and 250 ml of chloroform, and the mixture is heated under reflux for 24 hours while care is taken to exclude moisture. The reaction mixture is then cooled and made basic with 10% aqueous potassium hydroxide.

後処理

  1. customA one liter three-neck flask equipped with a stirrer, condenser
  2. temperatureheating mantle
  3. temperaturethe mixture is heated
  4. temperatureunder reflux for 24 hours while care
  5. temperatureThe reaction mixture is then cooled

出典と根拠

ORDレコード
ord-5fe4ce41940e4c1d9dbd8a1d99c88bba
出典データセット
uspto-grants-1978_11
特許番号
USRE029843

反応ノート

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