1-Propanol → HCID 22759335、化合物

HRID 1704372ノート

反応式

HRID 1704372 の反応式
[C:1]([CH:4]([CH2:16][CH2:17][CH2:18][CH:19]1[O:21][CH2:20]1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])(=[O:3])[CH3:2].[CH2:22]([OH:25])[CH2:23][CH3:24].[OH-].[Na+]>O>[C:1]([CH:4]([CH2:16][CH2:17][CH2:18][CH:19]([OH:21])[CH2:20][O:25][CH2:22][CH2:23][CH3:24])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 10311-PropanolHCID 14798Sodium HydroxideHCID 22759269HCID 22759269、化合物

生成物 1

HCID 22759335HCID 22759335、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of ethyl 8-acetyl-12,13-epoxytridecanoate (14.9 g., 0.05 mole), propanol (60 ml.), sodium hydroxide (6.0 g., 0.15 mole) and water (15 ml.) is stirred 4 hours at 40°-45° and then heated 1 hour on the steam bath. The mixture is cooled, treated with water (250 ml.) and extracted with ether. The aqueous solution is acidified with hydrochloric acid. The oily product is taken up in ether, washed with water, and dried over sodium sulfate. Evaporation of the ether leaves the title compound as a pale yellow oil. Purification is effected by column chromatography on silica gel with 2% methanol in chloroform as the eluant.

後処理

  1. temperatureheated 1 hour on the steam bath
  2. temperatureThe mixture is cooled
  3. extractionextracted with ether
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of the ether

出典と根拠

ORDレコード
ord-07fe3e0446e345adbe07e4699dcf190a
出典データセット
uspto-grants-1978_11
特許番号
US04126629

反応ノート

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