反応式
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.C[Si](N[Si](C)(C)C)(C)C.Cl[Sn](Cl)(Cl)Cl.C(O[CH:28]1[CH2:32][CH2:31][CH2:30][O:29]1)(=O)C.COC1CCCO1>C(Cl)CCl>[O:29]1[CH2:30][CH2:31][CH2:32][CH:28]1[N:6]1[CH:7]=[C:2]([F:1])[C:3](=[O:9])[NH:4][C:5]1=[O:8]参加物
7
実験手順
0.65 g. (5 mmol) of 5-fluorouracil was agitated in 50 ml. of absolute ethylene chloride for one hour with 0.65 g. (4 mmol) of HMDS, 0.43 g. (4 mmol) of TCS, and 1.56 g. (6 mmol) of SnCl4 ; then 0.65 g. (5 mmol) of 2-acetoxytetrahydrofuran or 0.51 g. (5 mmol) of 2-methoxytetrahydrofuran was added to the mixture, and the latter was agitated for 2 hours and 4 hours, respectively, at 24° C. The mixture was worked up as described in Example 1, giving in an 87% yield N1 -(2-tetrahydrofuryl)-5-fluorouracil, m.p. 165°-167° C.
後処理
- customat 24° C
出典と根拠
- ORDレコード
- ord-9070a9e3beac4190a465513a1d707e4b
- 出典データセット
- uspto-grants-1980_06
- 特許番号
- US04209613
関連ノート
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