Pyrazole → HCID 178522630、化合物

HRID 1708850ノート

反応式

HRID 1708850 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13](Br)[C:12]([NH:17][C:18](=[O:28])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=2)=[N:11]1.[NH:29]1[CH:33]=[CH:32][CH:31]=[N:30]1>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13]([C:33]2[CH:32]=[CH:31][NH:30][N:29]=2)[C:12]([NH:17][C:18](=[O:28])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=2)=[N:11]1

参加物

4

反応物 2

HCID 1048PyrazoleHCID 23037982HCID 23037982、化合物

生成物 1

HCID 178522630HCID 178522630、化合物収率 66.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Next, 304 g (0.6 mol) of the 1-(2,4,6-trichlorophenyl)-3-(3-nitrobenzamido)-4-bromo-5-oxo-2pyrazoline and 163 g (2.4 mol) of pyrazole were mixed well and then heated to react for about 5 to 6 hours at 80° to 90° C in a stream of nitrogen gas. The mixture was then cooled to room temperature, 700 ml of acetonitrile was added, and the deposited crystals were thereafter filtered to obtain 197 g (66 %) of 1-(2,4,6-trichlorophenyl)-3-(3-nitrobenzamido)-4-pyrazolyl-5-oxo-2-pyrazoline.

後処理

  1. temperatureheated
  2. customto react for about 5 to 6 hours at 80° to 90° C in a stream of nitrogen gas
  3. filtrationthe deposited crystals were thereafter filtered

出典と根拠

ORDレコード
ord-1064dbd6c4c64b79b9e2867add392723
出典データセット
uspto-grants-1990_08
特許番号
US04946771

反応ノート

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