N-bromobutanimide → 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide

HRID 1711293

反応式

HRID 1711293 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.C1C(=O)N([Br:23])C(=O)C1>C(Cl)Cl>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])=[O:9])=[CH:4][C:3]=1[Br:23]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 8326274-Amino-N-(1,1-dimethylethyl)benzenesulfonamide

生成物 1

HCID 548502844-amino-3-bromo-N-tert-butyl-benzenesulfonamide収率 53.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-amino-N-tert-butyl-benzenesulfonamide (J. Med. Chem. (2003), 46(16), 3463-3475, 228 mg, 1.00 mmol) in DCM (10 mL), NBS (178 mg, 1.00 mmol) was added. The resulting mixture was stirred at RT for 30 min and washed with satd NaHCO3 (10 mL) and 10% aq Na2S2O3 (10 mL). The organic layer was separated, dried and concentrated to obtain 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide (163 mg, 53%).

後処理

  1. washwashed with satd NaHCO3 (10 mL) and 10% aq Na2S2O3 (10 mL)
  2. customThe organic layer was separated
  3. customdried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-82168f1fbbe246799a59bd1f0f3f1298
出典データセット
uspto-grants-2010_09
特許番号
US07790724B2

関連ノート

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