Lithium Hydroxide → (1R,2R)-2-(Pyridin-4-yl)cyclopropane-1-carboxylic acid
反応式
[N:1]1[CH:6]=[CH:5][C:4]([C@@H:7]2[CH2:9][C@H:8]2[C:10]([O:12]CC)=[O:11])=[CH:3][CH:2]=1.[OH-].[Li+]>C1COCC1.O.Cl>[N:1]1[CH:6]=[CH:5][C:4]([C@@H:7]2[CH2:9][C@H:8]2[C:10]([OH:12])=[O:11])=[CH:3][CH:2]=1参加物
6
実験手順
To a solution of ethyl trans-2-pyridin-4-ylcyclopropanecarboxylate (0.918 g, 4.80 mmol) in THF (10 mL) and water (10 mL) was added lithium hydroxide (0.345 g, 14.4 mmol). The reaction mixture was allowed to stir at rt for 24 h and then diluted with 2N HCl (10 mL). The mixture was concentrated to give trans-2-pyridin-4-ylcyclopropanecarboxylic acid which was used without purification in the next step. LCMS: (FA) ES+ 164.0, ES-162.1.
後処理
- concentrationThe mixture was concentrated
出典と根拠
- ORDレコード
- ord-b055db93d851421b8e9c37884e7a48bb
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07795249B2
反応ノート
読み込み中…