Oxalyl chloride → 6-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carbonyl chloride

HRID 1713390ノート

反応式

HRID 1713390 の反応式
[CH3:1][N:2]([CH3:18])[S:3]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([N:12]=[CH:13][C:14]=2[C:15](O)=[O:16])[CH:11]=1)(=[O:5])=[O:4].C(Cl)(=O)C([Cl:22])=O>C(Cl)(Cl)Cl>[CH3:1][N:2]([CH3:18])[S:3]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([N:12]=[CH:13][C:14]=2[C:15]([Cl:22])=[O:16])[CH:11]=1)(=[O:5])=[O:4]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 685038746-(N,N-Dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxylic acid

生成物 1

HCID 866251176-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

6-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid (200 mg, 0.57 mmol) are dissolved in 4 ml chloroform and oxalylchloride (97 μl, 1.14 mmol; Fluka) are added. The reaction is refluxed for 3 hours and then volatiles are removed under reduced pressure. The crude product is directly used in the next step.

後処理

  1. temperatureThe reaction is refluxed for 3 hours
  2. customvolatiles are removed under reduced pressure

出典と根拠

ORDレコード
ord-5694a6fc30974663b948688be9fd5858
出典データセット
uspto-grants-2010_09
特許番号
US07795273B2

反応ノート

読み込み中…