Methyl iodide → HCID 23155891、化合物
反応式
O1CCC[CH2:2]1.[CH3:6][N:7]1[C:16](=[O:17])[C:15]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=2[N:9]=[C:8]1[S-:18].[K+].CI>CN(C)C=O>[CH3:6][N:7]1[C:16](=[O:17])[C:15]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=2[N:9]=[C:8]1[S:18][CH3:2]参加物
5
実験手順
To a mixture of 10 ml of tetrahydrofuran and 5 ml of dimethylformamide, 340 mg of potassium 3-methyl-4-oxo-3,4,5,6,7,8-hexahydroquinazoline-2-thiolate was added, followed by addition of 210 mg of methyl iodide and an overnight's stirring at room temperature. The solution was concentrated, to which chloroform was added, followed by washing with saturated brine and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 310 mg (quantitative) of 3-methyl-2-methylthio-5,6,7,8-tetrahydro-3H-quinazolin-4-one was obtained.
後処理
- additionwas added
- concentrationThe solution was concentrated, to which chloroform
- additionwas added
- washby washing with saturated brine
- dry with materialdrying over anhydrous magnesium sulfate
- distillationDistilling the solvent off under reduced pressure
出典と根拠
- ORDレコード
- ord-c954db947ff84596914c90f8b74c76de
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07799775B2
反応ノート
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