Ammonia → Irbesartan

HRID 1715732

反応式

HRID 1715732 の反応式
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:14]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[C:27]([C:28]4[N:32]=[N:31][NH:30][N:29]=4)=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:18][CH:17]=2)[C:12](=[O:13])[C:7]2([CH2:11][CH2:10][CH2:9][CH2:8]2)[N:6]=1.Cl.N>C1(C)C=CC=CC=1.O>[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:14]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=3[C:28]3[N:29]=[N:30][NH:31][N:32]=3)=[CH:20][CH:21]=2)[C:12](=[O:13])[C:7]2([CH2:8][CH2:9][CH2:10][CH2:11]2)[N:6]=1

参加物

5

反応物 2

HCID 222AmmoniaHCID 11568906Irbesartan hydrochloride

生成物 1

HCID 3749Irbesartan

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

100 g of anhydrous irbesartan hydrochloride was taken in a mixture of 250 ml toluene and 250 ml water. The pH of the reaction mass was adjusted to 6.5 to 7.0 with aqueous ammonia at 25-30° C. and stirred for about 30 minutes and filtered. The product was dried at 60° C. under vacuum to yield Form A of irbesartan free base.

後処理

  1. filtrationfiltered
  2. customThe product was dried at 60° C. under vacuum

出典と根拠

ORDレコード
ord-63630d540c32495c932d321ae0909986
出典データセット
uspto-grants-2010_09
特許番号
US07799928B2

関連ノート

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