1H-Indole-2-carboxylic acid, 1-methyl- → 1-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-indole-2-carboxamide

HRID 17161

反応式

HRID 17161 の反応式
C(Cl)(=O)C(Cl)=O.[CH3:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:17]([OH:19])=O.[CH3:20][C:21]1([CH3:35])[C:25]([CH3:27])([CH3:26])[O:24][B:23]([C:28]2[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=2)[O:22]1.C(N(C(C)C)CC)(C)C>CN(C)C=O.ClCCl>[CH3:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:17]([NH:32][C:31]1[CH:30]=[CH:29][C:28]([B:23]2[O:24][C:25]([CH3:27])([CH3:26])[C:21]([CH3:35])([CH3:20])[O:22]2)=[CH:34][CH:33]=1)=[O:19]

参加物

7

反応物 4

HCID 276951H-Indole-2-carboxylic acid, 1-methyl-HCID 65578Oxalyl chlorideHCID 81531DiisopropylethylamineHCID 27346204-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

生成物 1

HCID 184505431-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-indole-2-carboxamide収率 70.2%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of oxalyl chloride (0.35 mL) and dimethylformamide (1 drop) was added to a solution of 1-methyl-1H-2-indolecarboxylic acid (440 mg, 2.51 mmol) in dichloromethane (10 mL). After one hour the mixture was evaporated, dissolved in dichloromethane (10 mL), and added to a mixture of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (500 mg, 2.28 mmol) and diisopropylethylamine (0.35 mL) in dichloromethane (10 mL). After 16 hours the mixture was washed with water (10 mL), dried (MgSO4), filtered, concentrated, and purified by flash column chromatography to provide the desired product (600 mg, 1.60 mmol) after lyophilization: MS m/e 377.4 (M+H)+.

後処理

  1. customAfter one hour the mixture was evaporated
  2. dissolutiondissolved in dichloromethane (10 mL)
  3. washAfter 16 hours the mixture was washed with water (10 mL)
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. custompurified by flash column chromatography

出典と根拠

ORDレコード
ord-00dd9d9dddeb4439adc214beea6eb3c3
出典データセット
uspto-grants-2010_06
特許番号
US07737160B2

関連ノート

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