4-Aminobenzoic Acid → Carbamazepine 4-aminobenzoic acid

HRID 1716192

反応式

HRID 1716192 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:16]([NH2:18])=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[NH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=1>CO>[CH:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([NH2:18])=[O:17])[C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[CH:7]=[CH:8][C:9]=2[CH:10]=1.[NH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=1

参加物

4

反応物 2

HCID 9784-Aminobenzoic AcidHCID 2554Carbamazepine

生成物 1

HCID 68425507Carbamazepine 4-aminobenzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

40 mg (0.1693 mmol) of carbamazepine and 30 mg (0.1421 mmol) of 4-aminobenzoic acid were dissolved in approximately 3 mL methanol. Slow evaporation of the solvent yielded clear plates of carbamazepine:4-aminobenzoic acid (2:1) co-crystal. The co-crystal was analyzed via IR spectroscopy and single-crystal x-ray diffraction.

後処理

  1. customevaporation of the solvent

出典と根拠

ORDレコード
ord-44bb3b9cb73747d187051a5a3f9e2af5
出典データセット
uspto-grants-2010_09
特許番号
US07803786B2

関連ノート

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