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Sodium Hydroxide → 3-(1-{5-[6-(4-Methyl-pyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidin-4-yl)propionic acid

HRID 1716524
ノート
印刷プレビュー

反応式

HRID 1716524 の反応式
C[O:2][C:3](=[O:31])[CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[S:13][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:24]4[CH:29]=[C:28]([CH3:30])[CH:27]=[CH:26][N:25]=4)[N:18]=3)=[CH:15][N:16]=2)[CH2:8][CH2:7]1.[OH-].[Na+]>O1CCCC1.CO>[CH3:30][C:28]1[CH:27]=[CH:26][N:25]=[C:24]([NH:23][C:19]2[N:18]=[C:17]([C:14]3[S:13][C:12]([N:9]4[CH2:8][CH2:7][CH:6]([CH2:5][CH2:4][C:3]([OH:31])=[O:2])[CH2:11][CH2:10]4)=[N:16][CH:15]=3)[CH:22]=[CH:21][CH:20]=2)[CH:29]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 587069463-(1-{5-[6(4-Methyl-pyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidin-4-yl)propionic acid methyl ester

生成物 1

HCID 441765793-(1-{5-[6-(4-Methyl-pyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidin-4-yl)propionic acid収率 59%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran
溶媒

実験手順

To a mixed solution of 3-(1-{5-[6-(4-methyl-pyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidine-4-)propionic acid methyl ester (250 mg, 0.57 mmol) obtained in Step 3 in tetrahydrofuran (5 ml) and methanol (5 ml), 4N sodium hydroxide (1.5 ml, 6.0 mmol) was added and the mixture was stirred at room temperature for 12 hours. The concentrate obtained by concentrating the reaction solution in vacuo was neutralized with 0.1N hydrochloric acid, and the precipitated solid was collected by filtration, washed with water and the title compound (142 mg, 59%) was obtained.

後処理

  1. customThe concentrate obtained
  2. concentrationby concentrating the reaction solution in vacuo
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water

出典と根拠

ORDレコード
ord-1222bb7885754c168674955ec2b93ed4
出典データセット
uspto-grants-2010_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07803801B2

反応ノート

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