Water → HCID 178473413、化合物
反応式
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([OH:11])=[N:5][NH:6]2.O.Cl[C:14]([O:16][CH2:17][CH3:18])=[O:15]>N1C=CC=CC=1>[CH2:17]([O:16][C:14]([N:6]1[C:7]2[C:3](=[C:2]([Br:1])[CH:10]=[CH:9][CH:8]=2)[C:4]([OH:11])=[N:5]1)=[O:15])[CH3:18]参加物
5
実験手順
To a room temperature suspension of 4-Bromo-1H-indazol-3-ol CLXXXIII (3.19 g, 15.0 mmol) in pyridine (13 ml) and H2O (20 ml) was dropwise added ethyl chloroformate (1.43 ml, 15.0 mmol). After stirring 18 hours at room temperature, the mixture was cooled to 0° C., and the precipitate was filtered and washed with cold AcOH (10 ml in 5 ml of H2O). The solid was dried in vacuo affording 4-Bromo-3-hydroxy-indazole-1-carboxylic acid ethyl ester CLXXXIV as a yellow powder (2.97 g, 69% yield).
後処理
- temperaturethe mixture was cooled to 0° C.
- filtrationthe precipitate was filtered
- washwashed with cold AcOH (10 ml in 5 ml of H2O)
- customThe solid was dried in vacuo
出典と根拠
- ORDレコード
- ord-9f0bb4feebb74d5bb9b8743311cab94d
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07803830B2
反応ノート
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