2-(Diisopropylamino)ethyl chloride → 4-Diisopropylamino 2-(2-pyridyl)butyronitrile

HRID 1719676

反応式

HRID 1719676 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]#[N:9].Cl[CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15].[OH-].[Na+]>[Cl-].C([N+](C)(C)C)C1C=CC=CC=1.O>[CH:14]([N:13]([CH:17]([CH3:19])[CH3:18])[CH2:12][CH2:11][CH:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:8]#[N:9])([CH3:16])[CH3:15]

参加物

6

反応物 3

HCID 73122-(Diisopropylamino)ethyl chlorideHCID 14798Sodium HydroxideHCID 75959Pyridine-2-acetonitrile

生成物 1

HCID 133196744-Diisopropylamino 2-(2-pyridyl)butyronitrile

試薬・触媒・溶媒 2

HCID 5963Benzyltrimethylammonium chloride触媒HCID 962Water溶媒

反応条件

温度
35 °C

実験手順

8 g of 2-pyridyl acetonitrile, 8.8 g of 1-chloro 2-diisopropylamino ethane and 0.27 g of benzyltrimethylammonium chloride are mixed, then, maintaining the temperature below 35° C., 35 ml of 50% sodium hydroxide solution are added. The mixture is heated to 35° C. for 5 hours. After cooling, it is diluted with water and extracted with ether. The organic phase is separated and dried over sodium sulfate, then the solvent is evaporated to dryness.

後処理

  1. additionare added
  2. temperatureAfter cooling
  3. extractionextracted with ether
  4. customThe organic phase is separated
  5. dry with materialdried over sodium sulfate
  6. customthe solvent is evaporated to dryness

出典と根拠

ORDレコード
ord-1a2d2735dbf04a278e2ad804d8cd1815
出典データセット
uspto-grants-1985_09
特許番号
US04542134

関連ノート

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