Hydrogen Bromide → 4-Chloroquinolin-6-ol

HRID 1720276

反応式

HRID 1720276 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12]C)[CH:10]=2)[N:5]=[CH:4][CH:3]=1.Br.[OH-].[Na+]>O>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 2283484-Chloro-6-methoxyquinoline

生成物 1

HCID 184331324-Chloroquinolin-6-ol収率 56.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 4.99 g (18.1 mmol) of 4-chloro-6-methoxyquinoline and 50 mL of 48% hydrobromic acid is heated under reflux for seven hours. Upon cooling to room temperature, the reaction solution afforded a dark solid that was then slurried in water. The aqueous mixture was adjusted to pH 10 by the addition of 4N sodium hydroxide. The resulting solid was filtered, washed with water and air-dried to give 1.83 g (56%) of 4-chloroquinolin-6-ol: m.p. 223° C.

後処理

  1. temperatureunder reflux for seven hours
  2. customthe reaction solution afforded a dark solid
  3. filtrationThe resulting solid was filtered
  4. washwashed with water
  5. customair-dried

出典と根拠

ORDレコード
ord-c0fdfe9b5da74a6c90547c030d1edfe9
出典データセット
uspto-grants-1996_04
特許番号
US05506235

関連ノート

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