N-bromobutanimide → 2-Ethoxycarbonylimino-3-(3-trifluoromethylpheny)-5-bromothiazoline

HRID 1721042

反応式

HRID 1721042 の反応式
[CH2:1]([O:3][C:4]([N:6]=[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[CH2:10][CH2:9][S:8]1)=[O:5])[CH3:2].[Br:22]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4]([N:6]=[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:20])([F:21])[F:19])[CH:13]=2)[CH:10]=[C:9]([Br:22])[S:8]1)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 542258332-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

生成物 1

HCID 540969932-Ethoxycarbonylimino-3-(3-trifluoromethylpheny)-5-bromothiazoline収率 45.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl) thiazolidine (1.6 g) and N-bromosuccinimide (2 g) in chloroform (50 ml) was refluxed for 10 hours. After cooling, the reaction mixture was washed with an aqueous sodium sulfite solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 0.9 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromothiazoline (Compound No. 30).

後処理

  1. temperatureAfter cooling
  2. washthe reaction mixture was washed with an aqueous sodium sulfite solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-29f33485db5844ac8296bc2d529b5278
出典データセット
uspto-grants-1996_04
特許番号
US05508415

関連ノート

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