Sodium Hydroxide → (1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one oxime

HRID 1721501ノート

反応式

HRID 1721501 の反応式
[OH-:1].[Na+].[C@:3]12([CH3:13])[C:10]([CH3:12])([CH3:11])[CH:7]([CH2:8][CH2:9]1)[CH2:6][C:4]2=O.Cl.[NH2:15]O>C(O)C.O>[C@:3]12([CH3:13])[C:10]([CH3:12])([CH3:11])[CH:7]([CH2:8][CH2:9]1)[CH2:6][C:4]2=[N:15][OH:1]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 9543187Npc54264

生成物 1

HCID 76039(1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one oxime

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

Sodium hydroxide (15.03 g; 375.50 mmol) is added carefully to a solution, which is boiling under reflux, of (1R)(+)camphor (10.01 g; 65.86 mmol) and hydroxylamine hydrochloride (10.04 g; 144.46 mmol) in 150 ml of ethanol and 20 ml of water. After 7 hours, the reaction solution is cooled down, diluted with water and filtered. The filtrate is brought to a pH of 5-6 using acetic acid. After renewed filtration, the oxime 19 is obtained (3.81 g, 35% of theory) (m.p. 188°-20° C.).

後処理

  1. temperaturethe reaction solution is cooled down
  2. filtrationfiltered
  3. filtrationfiltration

出典と根拠

ORDレコード
ord-f81fe3ffaf2a48548fa4631071726f13
出典データセット
uspto-grants-1996_04
特許番号
US05510504

反応ノート

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