Water → 2-(2-Propylimidazol-1-yl)propan-1-ol

HRID 1721886ノート

反応式

HRID 1721886 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C:10]1[N:11]([CH:15]([CH3:21])[C:16](OCC)=[O:17])[CH:12]=[CH:13][N:14]=1)[CH2:8][CH3:9].O.[OH-].[Na+]>O1CCCC1>[CH2:7]([C:10]1[N:11]([CH:15]([CH3:21])[CH2:16][OH:17])[CH:12]=[CH:13][N:14]=1)[CH2:8][CH3:9]

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 20070368Ethyl-2-(2-propylimidazol-1-yl)propanoateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 200703742-(2-Propylimidazol-1-yl)propan-1-ol収率 73.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

Lithium aluminum hydride (2.5 g) was suspended in tetrahydrofuran (40 ml). Ethyl 2-(2-propylimidazol-1-yl)propanate [9.2 g] in tetrahydrofuran (40 ml) was added with stirring at 0° C. The reaction was refluxed for 3 hours, cooled to 0° C., water (3 ml) was added dropwise followed by 15% sodium hydroxide (3 ml) and a further portion of water (9 ml). The suspension was filtered through solka-flok and the solvent removed under reduced pressure. Dichloromethane (50 ml) was added, the organic phase washed with brine (25 ml) dried over magnesium sulphate and the solvent removed under reduced pressure yielding the title compound as a white foam 5.4 g (67%).

後処理

  1. temperatureThe reaction was refluxed for 3 hours
  2. temperaturecooled to 0° C.
  3. filtrationThe suspension was filtered through solka-flok and the solvent
  4. customremoved under reduced pressure
  5. additionDichloromethane (50 ml) was added
  6. washthe organic phase washed with brine (25 ml)
  7. dry with materialdried over magnesium sulphate
  8. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-3546e09500dc4a36a4942db3a2a462ea
出典データセット
uspto-grants-1989_08
特許番号
US04853392

反応ノート

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