反応式
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=O)[C:4]=2[CH:3]=[CH:2]1.[OH-].[Na+].[CH3:14][C:15]([NH:18][CH2:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:30])[CH3:29])=[CH:24][CH:23]=1)([CH3:17])[CH3:16]>C(O)C.O>[CH3:17][C:15]([NH:18][CH2:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:30])[CH:29]=[CH:10][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]3[C:4]=2[CH:3]=[CH:2][NH:1]3)=[CH:24][CH:23]=1)([CH3:14])[CH3:16]参加物
実験手順
A mixture of 2.55 g of indole-4-carboxaldehyde and 4 ml of 50% sodium hydroxide solution was added with stirring under an inert atmosphere to a solution of 3.5 g of the product of Step B in 40 ml of ethanol and after stirring for 24 hours, the mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed with water and the wash water was reextracted with an 8-2 chloroform-methanol mixture. The extract was washed with water and aqueous sodium chloride solution and the combined organic phases were dried over a deshydrant and were evaporated to dryness. The residue was chromatographed over silica gel and eluted with a 9-1 ethyl acetate-triethylamine mixture to obtain 4.3 g of 1-[4-{-2-(1,1-dimethylamino)-ethoxy}-phenyl]-3-[1H-indol-4-yl]-2-propen-1-one (E) melting at ≃162° C.
後処理
- additionwas added
- extractionextracted with ethyl acetate
- washThe organic phase was washed with water
- washThe extract was washed with water and aqueous sodium chloride solution
- customthe combined organic phases were dried over a deshydrant
- customwere evaporated to dryness
- customThe residue was chromatographed over silica gel
- washeluted with a 9-1 ethyl acetate-triethylamine mixture
出典と根拠
- ORDレコード
- ord-0c3e604ab6204dfc91fcba24e435a7b8
- 出典データセット
- uspto-grants-1989_08
- 特許番号
- US04853408
関連ノート
読み込み中…