Water → HCID 10976648、化合物

HRID 1722494ノート

反応式

HRID 1722494 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]([C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][C:20](O)=[O:21])=[CH:13][CH:12]=1)([CH3:10])[CH3:9].O.[OH-].[Na+]>C1COCC1.C(OCC)C>[CH3:10][C:8]([C:11]1[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][CH2:19][CH2:20][OH:21])=[CH:15][CH:16]=1)([CH3:7])[CH3:9]

参加物

7

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 50189424-(4-tert-butylphenyl)butanoic AcidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 10976648HCID 10976648、化合物収率 97.5%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

To a stirred suspension of lithium aluminum hydride (4.0 g, 0.105 mol) in THF (100 mL) at 0° C. under a nitrogen atmosphere was added a solution of 4-[4-(1,1-dimethylethyl)-phenyl]butanoic acid (10.31 g, 0.0455 mol) in THF (80 mL). The reaction was heated to reflux for 6 hours. The reaction was cooled to 0° C. and water (4 mL), 15% NaOH (4 mL) and water (12 mL) were carefully added. Ethyl ether (150 mL) was added, the mixture warmed to ambient temperature, and the precipitated salts were removed by filtration. Removal of solvent gave 9.15 g of 4-[4-(1,1-dimethylethyl)phenyl]-butanol as a colorless oil.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 6 hours
  3. temperaturethe mixture warmed to ambient temperature
  4. customthe precipitated salts were removed by filtration
  5. customRemoval of solvent

出典と根拠

ORDレコード
ord-3f98c29e59424beb82e54ee0bc67da41
出典データセット
uspto-grants-1989_08
特許番号
US04855462

反応ノート

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