Methyl iodide → N,N-Diethyl-2-methoxy-N-methylethan-1-aminium iodide

HRID 1724612ノート

反応式

HRID 1724612 の反応式
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:8][CH3:9])[CH2:6][CH3:7].[CH3:10][I:11]>O1CCCC1>[I-:11].[CH3:1][O:2][CH2:3][CH2:4][N+:5]([CH2:8][CH3:9])([CH2:6][CH3:7])[CH3:10]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 113555002-methoxyethyldiethylamine

生成物 1

HCID 71374868N,N-Diethyl-2-methoxy-N-methylethan-1-aminium iodide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Next, 41.2 g of the 2-methoxyethyldiethylamine was dissolved in 300 mL of tetrahydrofuran (Wako Pure Chemical Industries, Inc.), following which 20.0 mL of methyl iodide (Wako Pure Chemical Industries) was added under ice cooling. After 30 minutes, the ice bath was removed and stirring was carried out overnight at room temperature. The solvent in this reaction solution was driven off by vacuum distillation, and the resulting solids were recrystallized from an ethanol (Wako Pure Chemical Industries)—tetrahydrofuran mixture, yielding 80 g of 2-methoxyethyldiethylmethylammonium iodide.

後処理

  1. additionwas added under ice cooling
  2. customthe ice bath was removed
  3. waitwas carried out overnight at room temperature
  4. distillationThe solvent in this reaction solution was driven off by vacuum distillation
  5. customthe resulting solids were recrystallized from an ethanol (Wako Pure Chemical Industries)—tetrahydrofuran mixture

出典と根拠

ORDレコード
ord-6c30327a03604611a010dad45a74cf48
出典データセット
uspto-grants-2009_02
特許番号
US07488425B2

反応ノート

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